Gynecology & Obstetrics

Biography

SHORT CV Micheline MISRAHI Professor of Biochemistry and Molecular Biology Faculty of Medicine. University Paris-South Laboratory of Molecular Genetics Hopital Bicetre- 94275 Le Kremlin Bicetre FRANCE Telephone : 33-6-76-07-04-81 E-mail : micheline.misrahi@aphp.fr FIELD OF INTEREST : Molecular and cellular mechanisms in Reproductive and Thyroid Endocrinology. Nuclear receptors, membrane receptors. Genetics of Infertility. Primary ovarian failure. -RESEARCH EVALUATION AND TEACHING LAST TEN YEARS: • Director of the “Cell Signalling, Neurosciences, Endocrinology and Reproduction" Doctoral School, PhD program, Paris South • Member of the Scientific Council of the Paris-South Faculty of Medicine • Coordinator of the National Institute of Health and Medical Research-. INSERM Endocrinology-Diabetes Interface Committee • Member of the National Institute of Health and Medical Research- Committee of the National Research Program on Endocrinology and Reproduction • Member of the Scientific Council of the National Institute for Health and Medical Research-INSERM. • Expert at the National Agency of Drug Safety MAIN SCIENTIFIC RESULTS AND CONTRIBUTIONS • Cloning of the human progesterone cDNA and of the human gene • Cloning of the porcine LH/CG receptor and of the human gene. • Cloning of the human TSH receptor cDNA and of the human gene • Description of the basolateral targeting signals of the LH, FSH and TSH receptors • Descrition of a new signalling pathway involved in TSHR trafficking involving hScriB • Description of a two steps mecanism involved in the cleavage and shedding of the TSH receptor. • Development of an ELISA test for the study of neutral and functional auto-antibodies directed against the TSH receptor. • Description of loss of function and constitutive mutations of the TSH receptor in congenital hypothyroidism and non immune hyperthyroidism • Contribution to the description of the first genetic cause of non syndromic hypogonadotropic hypogonadism with mutations of the GnRH receptor • Description the first genetic cause of familial Spontaneous Ovarian Hyperstimulation Syndrome with broadening specificity of the FSH receptor. • Description of complete or partial genetic defects of the FSH receptor in Primary Ovarian Failure . • Description of male infertility with mutant Luteinizing hormone. More than 100 publications in the field including New Engl J Med, Science, Nature, J Clin Invest, PNAS, JAMA, EMBO J, . Citations : more than 5500 .

Research Interest

Molecular and cellular mechanisms in Reproductive and Thyroid Endocrinology